Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

An advanced search tutorial is now available on YouTube.

An advanced search tutorial is now available on YouTube.

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Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

Comentar - Enviar para um amigo

In October, 2010, a 55-year-old woman was admitted to our department for investigation of recurrent ascites. She had a medical history of adult polycystic kidney disease with hepatic cysts. 9 months earlier, she had started peritoneal dialysis, which was changed to haemodialysis after 5 months because of poor catheter flows and underdialysis. Subsequently, she developed ascites which required frequent drainage. The fluid was borderline for transudate or exudate with no malignant cells and was initially attributed to peritoneal irritation from her dialysis catheter.

Thalassaemia is one of the most common genetic diseases worldwide, with at least 60 000 severely affected individuals born every year. Individuals originating from tropical and subtropical regions are most at risk. Disorders of haemoglobin synthesis (thalassaemia) and structure (eg, sickle-cell disease) were among the first molecular diseases to be identified, and have been investigated and characterised in detail over the past 40 years. Nevertheless, treatment of thalassaemia is still largely dependent on supportive care with blood transfusion and iron chelation.

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors such as diet have been implicated, but not proven.

Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures less than 37°C and produce organ damage through two main pathways: vascular sludging (hyperviscosity syndrome, mainly in type I cryoglobulinaemia) and immune-mediated mechanisms (principally vasculitis, in mixed cryoglobulinaemia). Cryoglobulinaemia is associated with many illnesses, which can be broadly grouped into infections, autoimmune disorders, and malignancies; the most common cause is infection with hepatitis C virus.

A single oral dose of azithromycin is non-inferior to benzathine benzylpenicillin and avoids the need for injection equipment and medically trained personnel. A change to the simpler azithromycin treatment regimen could enable yaws elimination through mass drug administration programmes.

New England Journal of Medicine, Volume 366, Issue 4, Page 380-382, January 2012.

New England Journal of Medicine, Volume 366, Issue 4, Page 376-377, January 2012.

New England Journal of Medicine, Volume 366, Issue 4, Page 374-375, January 2012.

New England Journal of Medicine, Volume 366, Issue 4, Page 348-359, January 2012.

New England Journal of Medicine, Volume 366, Issue 4, Page 310-320, January 2012.